Review of Small Molecule Anticancer NF-κB Inhibitors

Cancer is one of the most common diseases in world. Th e transcription factor NF-κB plays a key role various physiological processes including immune response, cell proliferation, apoptosis and inflammation. Due to participation NF-kappa B signaling pathways carcinogenesis, angiogenesis, tumor resistance chemo- radiotherapy, considered be ideal target for pharmacological treatment cancer. paper presents literature review RSCI, PubMed, Scopus, Web Science, Chemical Abstracts NCCN databases other open access data. The carcinogenesis inhibitors were selected from all found. Inhibitors with antitumor activity analytical interest include Bruton tyrosine kinase (BTK) inhibitors, cellular proteins (c-IAP), proteasome inhibitor translocation nucleus. authors analyzed products diff erent development stages recorded varying degrees. are promising drug candidates, but since involved biological broad spectrum action can cause side eff ects, selective these compounds explored.